Zoladex/Zoladex LA Adverse Reactions

The following frequency categories for adverse drug reactions (ADRs) were calculated based on reports from ZOLADEX 3.6 mg/ZOLADEX LA 10.8 mg clinical trials and post-marketing sources.
Zoladex: (See Table 1.)

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Zoladex LA: The most commonly observed adverse reactions include hot flushes, hyperhidrosis and injection site reactions. The following convention has been used for classification of frequency: Very common (≥1/10), Common (≥1/100 to <1/10), Uncommon (≥1/1,000 to <1/100), Rare (≥1/10,000 to <1/1,000), Very rare (<1/10,000) and Unknown (cannot be estimated from the available data). (See Table 2.)

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Post-marketing experience: A small number of cases of changes in blood count, hepatic dysfunction, pulmonary embolism and interstitial pneumonia have been reported in connection with this medicine.
Rarely, breast cancer patients with metastases have developed hypercalcaemia on initiation of therapy. In the presence of symptoms indicative of hypercalcaemia (e.g. thirst), hypercalcaemia should be excluded.